| First Author | Meng Y | Year | 2017 |
| Journal | Behav Brain Res | Volume | 332 |
| Pages | 64-70 | PubMed ID | 28577919 |
| Mgi Jnum | J:249404 | Mgi Id | MGI:5921466 |
| Doi | 10.1016/j.bbr.2017.05.056 | Citation | Meng Y, et al. (2017) Immunization of Tg-APPswe/PSEN1dE9 mice with Abeta3-10-KLH vaccine prevents synaptic deficits of Alzheimer's disease. Behav Brain Res 332:64-70 |
| abstractText | The amyloid cascade hypothesis is widely accepted by researchers as the mechanism of Alzheimer's disease. Active immunization to eliminate Abeta depositions has been used in preclinical and clinical studies. Abeta3-10-KLH is a vaccine of the Abeta3-10 peptide combined with keyhole limpet hemocyanin (KLH). We immunized 2.5-month-old Tg-APPswe/PSEN1dE9 mice with Abeta3-10-KLH peptide and Abeta1-42 peptide to eliminate Abeta deposits in the brains of these transgenic mice. The results of immunohistochemical staining and transmission electron microscopy detection indicated that our new vaccine was more advantageous in protecting synaptic function and structure than the Abeta1-42 peptide. Abeta3-10-KLH peptide is an effective vaccine in the treatment of Alzheimer's disease. |
