| First Author | Wang L | Year | 2000 |
| Journal | Genetics | Volume | 154 |
| Issue | 1 | Pages | 357-62 |
| PubMed ID | 10628995 | Mgi Jnum | J:95127 |
| Mgi Id | MGI:3525113 | Doi | 10.1093/genetics/154.1.357 |
| Citation | Wang L, et al. (2000) Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene. Genetics 154(1):357-62 |
| abstractText | Mutations at the Werner helicase locus (WRN) are responsible for the Werner syndrome (WS). WS patients prematurely develop an aged appearance and various age-related disorders. We have generated transgenic mice expressing human WRN with a putative dominant-negative mutation (K577M-WRN). Primary tail fibroblast cultures from K577M-WRN mice showed three characteristics of WS cells: hypersensitivity to 4-nitroquinoline-1-oxide (4NQO), reduced replicative potential, and reduced expression of the endogenous WRN protein. These data suggest that K577M-WRN mice may provide a novel mouse model for the WS. |
