| First Author | Michaud J | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 19 | Pages | 4607-12 |
| PubMed ID | 16876794 | Mgi Jnum | J:112152 |
| Mgi Id | MGI:3655591 | Doi | 10.1016/j.febslet.2006.07.035 |
| Citation | Michaud J, et al. (2006) Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice. FEBS Lett 580(19):4607-12 |
| abstractText | Sphingosine-1-phosophate, generated from the phosphorylation of sphingosine by sphingosine kinase enzymes, is suggested to function as an intracellular second messenger for inflammatory mediators, including formyl peptide, C5a, and Fc. More recently, a role for sphingosine kinases during inflammation has also been proposed. Here we show that sphingosine kinase 1 knockout mice exhibit normal inflammatory cell recruitment during thioglycollate-induced peritonitis and that sphingosine kinase 1-null neutrophils respond normally to formyl peptide. In the collagen-induced arthritis model of rheumatoid arthritis, sphingosine kinase 1 knockout mice developed arthritis with normal incidence and severity. Our findings show that sphingosine kinase 1 is dispensable for inflammatory responses and support the need for more extensive studies of sphingosine kinases in inflammation. |
