| First Author | Field DJ | Year | 2017 |
| Journal | Immunol Res | Volume | 65 |
| Issue | 5 | Pages | 1089-1094 |
| PubMed ID | 28914425 | Mgi Jnum | J:320905 |
| Mgi Id | MGI:6880881 | Doi | 10.1007/s12026-017-8951-x |
| Citation | Field DJ, et al. (2017) Platelet factor 4 increases bone marrow B cell development and differentiation. Immunol Res 65(5):1089-1094 |
| abstractText | Platelet factor 4 (PF4) is a megakaryocyte-/platelet-derived chemokine with diverse functions as a regulator of vascular and immune biology. PF4 has a central role in vessel injury responses, innate immune cell responses, and T-helper cell differentiation. We have now discovered that PF4 has a direct role in B cell differentiation in the bone marrow. Mice lacking PF4 (PF4(-/-) mice) had fewer developing B cells in the bone marrow beginning after the pre-pro-B cell stage of differentiation. In vitro, PF4 increased the differentiation of hematopoietic progenitors to B cell lineage cells, indicating that PF4 has a direct effect on B cell differentiation. STAT5 activation is essential in early B cell development and PF4 increased the phosphorylation of STAT5. Taken together, these data demonstrate that PF4 has an important role in increasing B cell differentiation in the bone marrow environment. |
