| First Author | Natividad KD | Year | 2013 |
| Journal | PLoS One | Volume | 8 |
| Issue | 3 | Pages | e57469 |
| PubMed ID | 23554861 | Mgi Jnum | J:199519 |
| Mgi Id | MGI:5502978 | Doi | 10.1371/journal.pone.0057469 |
| Citation | Natividad KD, et al. (2013) Interleukin-27 signaling promotes immunity against endogenously arising murine tumors. PLoS One 8(3):e57469 |
| abstractText | Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-27 in immunity against tumors that develop in situ and in tumor immunosurveillance remain undefined. In this study, we demonstrate that tumor development and growth are accelerated in IL-27 receptor alpha (Il27ra)-deficient mice. Enhanced tumor growth in both carcinogen-induced fibrosarcoma and oncogene-driven mammary carcinoma was associated with decreased interferon-gamma production by CD4 and CD8 T cells and increased numbers of regulatory T-cells (Treg). This is the first study to show that IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent. |
