| First Author | Tung B | Year | 2017 |
| Journal | Proc Natl Acad Sci U S A | Volume | 114 |
| Issue | 5 | Pages | E707-E716 |
| PubMed ID | 28096336 | Mgi Jnum | J:240610 |
| Mgi Id | MGI:5888797 | Doi | 10.1073/pnas.1610383114 |
| Citation | Tung B, et al. (2017) beta-Catenin haploinsufficiency promotes mammary tumorigenesis in an ErbB2-positive basal breast cancer model. Proc Natl Acad Sci U S A 114(5):E707-E716 |
| abstractText | Aberrant activation of beta-catenin through its activity as a transcription factor has been observed in a large proportion of human malignancies. Despite the improved understanding of the beta-catenin signaling pathway over the past three decades, attempts to develop therapies targeting beta-catenin remain challenging, and none of these targeted therapies have advanced to the clinic. In this study, we show that part of the challenge in antagonizing beta-catenin is caused by its dual functionality as a cell adhesion molecule and a signaling molecule. In a mouse model of basal ErbB2 receptor tyrosine kinase 2 (ErbB2)-positive breast cancer (ErbB2KI), which exhibits aberrant beta-catenin nuclear signaling, beta-catenin haploinsufficiency induced aggressive tumor formation and metastasis by promoting the disruption of adherens junctions, dedifferentiation, and an epithelial to mesenchymal transition (EMT) transcriptional program. In contrast to the accelerated tumor onset observed in the haploid-insufficient ErbB2 tumors, deletion of both beta-catenin alleles in the ErbB2KI model had only a minor impact on tumor onset that further correlated with the retention of normal adherens junctions. We further showed that retention of adherens junctional integrity was caused by the up-regulation of the closely related family member plakoglobin (gamma-catenin) that maintained both adherens junctions and the activation of Wnt target genes. In contrast to the ErbB2KI basal tumor model, modulation of beta-catenin levels had no appreciable impact on tumor onset in an ErbB2-driven model of luminal breast cancer [murine mammary tumor virus promoter (MMTV-NIC)]. These observations argue that the balance of junctional and nuclear beta-catenin activity has a profound impact on tumor progression in this basal model of ErbB2-positive breast cancer. |
