| First Author | Stewart TJ | Year | 2008 |
| Journal | Cancer Invest | Volume | 26 |
| Issue | 3 | Pages | 237-49 |
| PubMed ID | 18317964 | Mgi Jnum | J:147923 |
| Mgi Id | MGI:3842906 | Doi | 10.1080/07357900701708419 |
| Citation | Stewart TJ, et al. (2008) Immune consequences of protracted host-tumor interactions in a transgenic mouse model of mammary carcinoma. Cancer Invest 26(3):237-49 |
| abstractText | A transgenic mouse model of autochthonous mammary carcinoma was chosen to study the impact of tumor progression on the immune system over an extended period. We found: i) that splenocyte numbers, particularly myeloid cells, increased concurrently with tumor burden; ii) the percentage of tumor-infiltrating Treg cells was similar to that in human breast cancer; iii) suppressed T cell proliferation and cytokine production and; iv) significantly elevated MCP-1 and TNF-alpha in the sera of tumor-bearing mice. The modified immune status in these tumor-bearing hosts is consistent with a 'syndrome' that likely impacts the efficacy of cancer immunosurveillance and response to therapy. |
