| First Author | Yamaguchi T | Year | 2004 |
| Journal | Brain Res | Volume | 1025 |
| Issue | 1-2 | Pages | 237-40 |
| PubMed ID | 15464766 | Mgi Jnum | J:92956 |
| Mgi Id | MGI:3055253 | Doi | 10.1016/j.brainres.2004.08.009 |
| Citation | Yamaguchi T, et al. (2004) Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1. Brain Res 1025(1-2):237-40 |
| abstractText | In the present study, we investigated the effects of pentylenetetrazol (PTZ), a chemical convulsant that interacts with the GABA(A) receptor, in mice lacking the phospholipase C (PLC)-related inactive protein-1 (PRIP-1). PRIP-1 knockout mice did not develop spontaneous behavioral seizure. PRIP-1 knockout mice had markedly shorter latencies until the first clonic convulsion (CL) and tonic extensor (TE) following PTZ administration and increased incidence of convulsion compared to those in wild-type mice. Furthermore, the mortality rate by PTZ in mice lacking the PRIP-1 was also significantly increased in comparison with that in wild-type mice. These findings suggested that mice lacking the PRIP-1 were hypersensitive to PTZ-induced convulsion, and PRIP-1 might play roles in suppressing excessive excitability via interactions with the GABA(A) receptor. |
