| First Author | Dietrich D | Year | 2003 |
| Journal | Neuron | Volume | 39 |
| Issue | 3 | Pages | 483-96 |
| PubMed ID | 12895422 | Mgi Jnum | J:131476 |
| Mgi Id | MGI:3773792 | Doi | 10.1016/s0896-6273(03)00430-6 |
| Citation | Dietrich D, et al. (2003) Functional specialization of presynaptic Cav2.3 Ca2+ channels. Neuron 39(3):483-96 |
| abstractText | Ca2+ influx into presynaptic terminals via voltage-dependent Ca2+ channels triggers fast neurotransmitter release as well as different forms of synaptic plasticity. Using electrophysiological and genetic techniques we demonstrate that presynaptic Ca2+ entry through Cav2.3 subunits contributes to the induction of mossy fiber LTP and posttetanic potentiation by brief trains of presynaptic action potentials while they do not play a role in fast synaptic transmission, paired-pulse facilitation, or frequency facilitation. This functional specialization is most likely achieved by a localization remote from the release machinery and by a Cav2.3 channel-dependent facilitation of presynaptic Ca2+ influx. Thus, the presence of Cav2.3 channels boosts the accumulation of presynaptic Ca2+ triggering presynaptic LTP and posttetanic potentiation without affecting the low release probability that is a prerequisite for the enormous plasticity displayed by mossy fiber synapses. |
