| First Author | Besin G | Year | 2012 |
| Journal | Eur J Immunol | Volume | 42 |
| Issue | 9 | Pages | 2491-504 |
| PubMed ID | 22736313 | Mgi Jnum | J:187941 |
| Mgi Id | MGI:5438759 | Doi | 10.1002/eji.201242421 |
| Citation | Besin G, et al. (2012) Dok-1 overexpression promotes development of gammadelta natural killer T cells. Eur J Immunol 42(9):2491-504 |
| abstractText | In T cells, two members of the Dok family, Dok-1 and Dok-2, are predominantly expressed. Recent evidence suggests that they play a negative role in T-cell signaling. In order to define whether Dok proteins regulate T-cell development, we have generated transgenic mice overexpressing Dok-1 in thymocytes and peripheral T cells. We show that overexpression of Dok-1 retards the transition from the CD4(-) CD8(-) to CD4(+) CD8(+) stage. Moreover, there is a specific expansion of PLZF-expressing Vgamma1.1(+) Vdelta6.3(+) T cells. This subset of gammadelta T cells acquires innate characteristics including rapid IL-4 production following stimulation and requiring SLAM-associated adaptor protein (SAP) for their development. Moreover, Dok-1 overexpression promotes the generation of an innate-like CD8(+) T-cell population that expresses Eomesodermin. Altogether, these findings identify a novel role for Dok-1 in the regulation of thymic differentiation and in particular, in the development of PLZF(+) gammadelta T cells. |
