| First Author | Carter LL | Year | 2007 |
| Journal | J Neuroimmunol | Volume | 182 |
| Issue | 1-2 | Pages | 124-34 |
| PubMed ID | 17182110 | Mgi Jnum | J:126829 |
| Mgi Id | MGI:3762077 | Doi | 10.1016/j.jneuroim.2006.10.006 |
| Citation | Carter LL, et al. (2007) PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol 182(1-2):124-34 |
| abstractText | Interactions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function. To determine the role of these molecules in autoimmune disease of the CNS, PD-1-/-, PD-L1-/- and PD-L2-/- mice were generated and immunized to induce experimental autoimmune encephalomyelitis (EAE). PD-1-/- and PD-L1-/- mice developed more severe EAE than wild type and PD-L2-/- mice. Consistent with this, PD-1-/- and PD-L1-/- cells produced elevated levels of the pro-inflammatory cytokines IFN-gamma, TNF, IL-6 and IL-17. These results demonstrate that interactions between PD-1/PD-L1, but not PD-1/PDL-2, are crucial in attenuating T cell responses in EAE. |
