| First Author | Maekawa M | Year | 2005 |
| Journal | Neurosci Res | Volume | 53 |
| Issue | 1 | Pages | 34-8 |
| PubMed ID | 15996778 | Mgi Jnum | J:103798 |
| Mgi Id | MGI:3610745 | Doi | 10.1016/j.neures.2005.05.008 |
| Citation | Maekawa M, et al. (2005) Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase. Neurosci Res 53(1):34-8 |
| abstractText | We evaluated the role of D-amino-acid oxidase on spatial learning and long-term potentiation (LTP) in the hippocampus, since this enzyme metabolizes D-amino-acids, some of which enhance the N-methyl-D-aspartate receptor functions. The Morris water maze learning and the LTP in the CA1 area of the hippocampal slice were observed in wild-type mice and mutant mice lacking D-amino-acid oxidase. The mutant mice showed significantly shorter platform search times in the water maze and significantly larger hippocampal LTPs than the wild-type mice. These results suggest that the abundant D-amino-acids in the mutant mouse brain facilitate hippocampal LTP and spatial learning. |
