| First Author | Hashimoto A | Year | 2005 |
| Journal | Brain Res | Volume | 1033 |
| Issue | 2 | Pages | 210-5 |
| PubMed ID | 15694926 | Mgi Jnum | J:95950 |
| Mgi Id | MGI:3528129 | Doi | 10.1016/j.brainres.2004.11.031 |
| Citation | Hashimoto A, et al. (2005) Mice lacking d-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801. Brain Res 1033(2):210-5 |
| abstractText | The behavioral effects produced by MK-801 (0.4 mg/kg) were compared in mutant DAO-/- mice lacking d-amino acid oxidase activity and normal DAO+/+ mice. Mutant mice display marked diminution of stereotypy and ataxia induced by MK-801 compared to normal mice. Because the d-serine level in the brain of mutant mice is significantly higher than that of normal mice, the elevated d-serine in the brain of mutant mice could antagonize MK-801-induced stereotypy and ataxia. |
