| First Author | Masliah E | Year | 2000 |
| Journal | Science | Volume | 287 |
| Issue | 5456 | Pages | 1265-9 |
| PubMed ID | 10678833 | Mgi Jnum | J:60638 |
| Mgi Id | MGI:1353749 | Doi | 10.1126/science.287.5456.1265 |
| Citation | Masliah E, et al. (2000) Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 287(5456):1265-9 |
| abstractText | To elucidate the role of the synaptic protein alpha-synuclein in neurodegenerative disorders, transgenic mice expressing wild-type human alpha-synuclein were generated. Neuronal expression of human alpha-synuclein resulted in progressive accumulation of alpha-synuclein-and ubiquitin-immunoreactive inclusions in neurons in the neocortex, hippocampus, and substantia nigra. Ultrastructural analysis revealed both electron-dense intranuclear deposits and cytoplasmic inclusions. These alterations were associated with loss of dopaminergic terminals in the basal ganglia and with motor impairments. These results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions. |
