| First Author | Masliah E | Year | 2011 |
| Journal | PLoS One | Volume | 6 |
| Issue | 4 | Pages | e19338 |
| PubMed ID | 21559417 | Mgi Jnum | J:172452 |
| Mgi Id | MGI:5007855 | Doi | 10.1371/journal.pone.0019338 |
| Citation | Masliah E, et al. (2011) Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of lewy body disease. PLoS One 6(4):e19338 |
| abstractText | Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are common causes of motor and cognitive deficits and are associated with the abnormal accumulation of alpha-synuclein (alpha-syn). This study investigated whether passive immunization with a novel monoclonal alpha-syn antibody (9E4) against the C-terminus (CT) of alpha-syn was able to cross into the CNS and ameliorate the deficits associated with alpha-syn accumulation. In this study we demonstrate that 9E4 was effective at reducing behavioral deficits in the water maze, moreover, immunization with 9E4 reduced the accumulation of calpain-cleaved alpha-syn in axons and synapses and the associated neurodegenerative deficits. In vivo studies demonstrated that 9E4 traffics into the CNS, binds to cells that display alpha-syn accumulation and promotes alpha-syn clearance via the lysosomal pathway. These results suggest that passive immunization with monoclonal antibodies against the CT of alpha-syn may be of therapeutic relevance in patients with PD and DLB. |
