| First Author | Masliah E | Year | 2005 |
| Journal | Neuron | Volume | 46 |
| Issue | 6 | Pages | 857-68 |
| PubMed ID | 15953415 | Mgi Jnum | J:99316 |
| Mgi Id | MGI:3581977 | Doi | 10.1016/j.neuron.2005.05.010 |
| Citation | Masliah E, et al. (2005) Effects of alpha-Synuclein Immunization in a Mouse Model of Parkinson's Disease. Neuron 46(6):857-68 |
| abstractText | Abnormal folding of alpha-synuclein (alpha-syn) is thought to lead to neurodegeneration and the characteristic symptoms of Lewy body disease (LBD). Since previous studies suggest that immunization might be a potential therapy for Alzheimer's disease, we hypothesized that immunization with human (h)alpha-syn might have therapeutic effects in LBD. For this purpose, halpha-syn transgenic (tg) mice were vaccinated with halpha-syn. In mice that produced high relative affinity antibodies, there was decreased accumulation of aggregated halpha-syn in neuronal cell bodies and synapses that was associated with reduced neurodegeneration. Furthermore, antibodies produced by immunized mice recognized abnormal halpha-syn associated with the neuronal membrane and promoted the degradation of halpha-syn aggregates, probably via lysosomal pathways. Similar effects were observed with an exogenously applied FITC-tagged halpha-syn antibody. These results suggest that vaccination is effective in reducing neuronal accumulation of halpha-syn aggregates and that further development of this approach might have a potential role in the treatment of LBD. |
