| First Author | Ma Y | Year | 2013 |
| Journal | Biol Open | Volume | 2 |
| Issue | 11 | Pages | 1187-91 |
| PubMed ID | 24244855 | Mgi Jnum | J:205113 |
| Mgi Id | MGI:5544121 | Doi | 10.1242/bio.20136031 |
| Citation | Ma Y, et al. (2013) Fascin 1 is dispensable for developmental and tumour angiogenesis. Biol Open 2(11):1187-91 |
| abstractText | The actin bundling protein fascin 1 is not expressed in adult epithelial tissues, but during development it is transiently expressed in many different cell types, and later in adults it is expressed in a subset of immune cells, nervous tissues, endothelial cells, smooth muscle cells and pericytes. In contrast to the wealth of knowledge about the role of fascin 1 in cancer cell migration and invasion, little is known about the involvement of fascin 1 in angiogenesis. We speculated that as angiogenesis involves migration and invasion of tissues by endothelial cells, fascin 1 might have a role in both normal and tumour angiogenesis. Here, we provide evidence that loss of fascin 1 causes relatively minor reductions to angiogenesis during embryonic, postnatal and cancerous development by examining E12.5 hindbrains, postnatal retinas and B16F0 tumour cell allografts in fascin 1-null mice. We also find that in fascin 1 null tissues, endothelial cells display reduced filopodia formation during sprouting. We thus propose that fascin 1 expression promotes angiogenesis via filopodia formation, but is largely dispensable for both normal and tumour angiogenesis. |
