| First Author | Durkin ME | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 5 | Pages | 1191-6 |
| PubMed ID | 15710412 | Mgi Jnum | J:96194 |
| Mgi Id | MGI:3529660 | Doi | 10.1016/j.febslet.2004.12.090 |
| Citation | Durkin ME, et al. (2005) DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development. FEBS Lett 579(5):1191-6 |
| abstractText | DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days post coitum. Histological analysis revealed that DLC-1-/- embryos had defects in the neural tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions. |
