| First Author | Homann D | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 4 | Pages | 463-72 |
| PubMed ID | 10549628 | Mgi Jnum | J:96857 |
| Mgi Id | MGI:3573753 | Doi | 10.1016/s1074-7613(00)80121-1 |
| Citation | Homann D, et al. (1999) Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. Immunity 11(4):463-72 |
| abstractText | Targeted immune regulation can be achieved by use of tissue-specific T cells and offers the potential for organ-specific suppression of destructive autoimmune processes. Here, we report the generation and characterization of insulin B chain-specific 'autoreactive' CD4+ regulatory T cells that locally suppress diabetogenic T cell responses against an unrelated self-antigen (viral transgene) in a virus-induced model for type 1 diabetes. Interleukin 4 (IL-4) is essential for prevention of diabetes since regulatory T cells cannot be induced in the absence of IL-4 or stat6 (IL-4 signaling pathway). Our observations demonstrate that autoreactive regulatory T cells can suppress autoreactive destructive T cell activity of differential antigenic specificity locally in the pancreatic draining lymph node, probably via cytokine-mediated modulation of antigen-presenting cells. |
