| First Author | Lee KY | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 8054 | PubMed ID | 26299309 |
| Mgi Jnum | J:224980 | Mgi Id | MGI:5689932 |
| Doi | 10.1038/ncomms9054 | Citation | Lee KY, et al. (2015) Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun 6:8054 |
| abstractText | Skeletal muscle is composed of both slow-twitch oxidative myofibers and fast-twitch glycolytic myofibers that differentially impact muscle metabolism, function and eventually whole-body physiology. Here we show that the mesodermal transcription factor T-box 15 (Tbx15) is highly and specifically expressed in glycolytic myofibers. Ablation of Tbx15 in vivo leads to a decrease in muscle size due to a decrease in the number of glycolytic fibres, associated with a small increase in the number of oxidative fibres. This shift in fibre composition results in muscles with slower myofiber contraction and relaxation, and also decreases whole-body oxygen consumption, reduces spontaneous activity, increases adiposity and glucose intolerance. Mechanistically, ablation of Tbx15 leads to activation of AMPK signalling and a decrease in Igf2 expression. Thus, Tbx15 is one of a limited number of transcription factors to be identified with a critical role in regulating glycolytic fibre identity and muscle metabolism. |
