Primary Identifier | MGI:3531485 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(LPV-TAg121)#Tvd |
Strain of Origin | (C57BL/6J X DBA/2)F2 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The transgene consists of a lymphotropic papovavirus (LPV) enhancer/early promoter and a mutant SV40 T antigen sequence truncated after amino acid 121 followed by 11 missense residues. The resulting protein includes the RB1-binding region but lacks the small t antigen and the TRP53 binding region. Regulatory sequences direct expression of the transgene in B- and T-lymphocytes and choroid plexus epithelium. |