| First Author | Golovkina TV | Year | 2000 |
| Journal | J Virol | Volume | 74 |
| Issue | 6 | Pages | 2752-9 |
| PubMed ID | 10684291 | Mgi Jnum | J:60602 |
| Mgi Id | MGI:1353713 | Doi | 10.1128/jvi.74.6.2752-2759.2000 |
| Citation | Golovkina TV (2000) A novel mechanism of resistance to mouse mammary tumor virus infection. J Virol 74(6):2752-9 |
| abstractText | Exogenous mouse mammary tumor virus (MMTV) is carried from the gut of suckling pups to the mammary glands by lymphocytes and induces mammary gland tumors. MMTV-induced tumor incidence in inbred mice of different strains ranges from 0 to as high as 100%. For example, mice of the C3H/HeN strain are highly susceptible, whereas mice of the I/LnJ strain are highly resistant. Of the different factors that together determine the susceptibility of mice to development of MMTV-induced mammary tumors, genetic elements play a major role, although very few genes that determine a susceptibility-resistance phenotype have been identified so far. Our data indicate that MMTV fails to infect mammary glands in I/LnJ mice foster nursed on viremic C3H/HeN females, even though the I/LnJ mammary tissue is not refractory to MMTV infection. Lymphocytes from fostered I/LnJ mice contained integrated MMTV proviruses and shed virus but failed to establish infection in the mammary glands of susceptible syngeneic (I x C3H.JK)F(1) females. Based on the susceptible-resistant phenotype distribution in N(2) females, both MMTV mammary gland infection and mammary gland tumor development in I/LnJ mice are controlled by a single locus. |
