| First Author | Gowing G | Year | 2009 |
| Journal | Exp Neurol | Volume | 220 |
| Issue | 2 | Pages | 267-75 |
| PubMed ID | 19733170 | Mgi Jnum | J:154464 |
| Mgi Id | MGI:4368052 | Doi | 10.1016/j.expneurol.2009.08.021 |
| Citation | Gowing G, et al. (2009) Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase. Exp Neurol 220(2):267-275 |
| abstractText | Macrophage colony stimulating factor (M-CSF) is a cytokine that regulates the survival, proliferation and maturation of microglial cells. Administration of M-CSF can promote neuronal survival in various models of central nervous system (CNS) injury. Here, in an attempt to induce a neuroprotective microglial cell phenotype and enhance motor neuron survival, mutant SOD1(G37R) transgenic mice were treated, weekly, with M-CSF starting at onset of disease. Unexpectedly, M-CSF accelerated disease progression in SOD1(G37R) mouse model of ALS. The shortened survival of M-CSF-treated animals was associated with diminished muscle innervation and enhanced adoption of a macrophage-like phenotype by microglial cells characterised by the upregulation of pro-inflammatory cytokines TNF-alpha and IL-1beta and of the phagocytic marker CD68. |
