| First Author | Wojno ED | Year | 2011 |
| Journal | J Immunol | Volume | 187 |
| Issue | 1 | Pages | 266-73 |
| PubMed ID | 21622862 | Mgi Jnum | J:175937 |
| Mgi Id | MGI:5287950 | Doi | 10.4049/jimmunol.1004182 |
| Citation | Wojno ED, et al. (2011) A role for IL-27 in limiting T regulatory cell populations. J Immunol 187(1):266-73 |
| abstractText | IL-27 is a cytokine that regulates Th function during autoimmune and pathogen-induced immune responses. Although previous studies have shown that regulatory T cells (Tregs) express the IL-27R, and that IL-27 inhibits forkhead box P3 upregulation in vitro, little is known about how IL-27 influences Tregs in vivo. The studies presented in this article show that mice that overexpress IL-27 had decreased Treg frequencies and developed spontaneous inflammation. Although IL-27 did not cause mature Tregs to downregulate forkhead box P3, transgenic overexpression in vivo limited the size of a differentiating Treg population in a bone marrow chimera model, which correlated with reduced production of IL-2, a vital cytokine for Treg maintenance. These data identify an indirect role for IL-27 in shaping the Treg pool. |
