| First Author | Ho SY | Year | 2020 |
| Journal | Int J Mol Sci | Volume | 21 |
| Issue | 12 | PubMed ID | 32575793 |
| Mgi Jnum | J:302423 | Mgi Id | MGI:6508272 |
| Doi | 10.3390/ijms21124403 | Citation | Ho SY, et al. (2020) Investigating the Role of PPARbeta/delta in Retinal Vascular Remodeling Using Pparbeta/delta-Deficient Mice. Int J Mol Sci 21(12):4403 |
| abstractText | Peroxisome proliferator-activated receptor (PPAR)beta/delta is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparbeta/delta-deficient mice. However, PPARbeta/delta's role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARbeta/delta is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparbeta/delta-haplodeficient mice. In summary, these results indicated a critical role of PPARbeta/delta in pathological angiogenesis and blood vessel remodeling in the retina. |
