| First Author | Biddle FG | Year | 1988 |
| Journal | Genome | Volume | 30 |
| Issue | 6 | Pages | 870-8 |
| PubMed ID | 3234755 | Mgi Jnum | J:9660 |
| Mgi Id | MGI:58117 | Doi | 10.1139/g88-140 |
| Citation | Biddle FG, et al. (1988) Assays of testis development in the mouse distinguish three classes of domesticus-type Y chromosome. Genome 30(6):870-8 |
| abstractText | The Y chromosome of Mus musculus poschiavinus interacts with the autosomal recessive gene tda-1b of the C57BL/6J laboratory strain of the house mouse to cause complete or partial sex reversal. Ovaries or ovotestes develop in a substantial proportion of the XY fetuses. Several different Y-specific DNA probes distinguish two major types of Y chromosome in the house mouse and they are represented by M. m. domesticus and M. m. musculus. The poschiavinus Y chromosome appears identical to the domesticus Y. The developmental distribution of the gonad types was examined in the first backcross or N2 generation of fetuses in C57BL/6J with six different domesticus-type Y chromosomes and, as controls, three different musculus-type Y chromosomes. Gonadal hermaphrodites were found with three of the six domesticus-type Y chromosomes. Both overall frequency and phenotypic distribution of types of gonadal hermaphrodites identify three classes of domesticus-type Y chromosome by their differential interaction with the C57BL/6J genetic background. |
