| First Author | Gorelik L | Year | 2001 |
| Journal | Nat Med | Volume | 7 |
| Issue | 10 | Pages | 1118-22 |
| PubMed ID | 11590434 | Mgi Jnum | J:72218 |
| Mgi Id | MGI:2152006 | Doi | 10.1038/nm1001-1118 |
| Citation | Gorelik L, et al. (2001) Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat Med 7(10):1118-22 |
| abstractText | Despite the existence of tumor-specific antigens and demonstrated presence of tumor-specific immune cells, the majority of tumors manage to avoid immune-mediated destruction. Various mechanisms have been suggested for tumor evasion from immune response. One such mechanism is thought to be mediated by transforming growth factor-beta (TGF-beta), an immunosuppressive cytokine found at the site of most tumors. We demonstrate here that T-cell-specific blockade of TGF-beta signaling allows the generation of an immune response capable of eradicating tumors in mice challenged with live tumor cells. In addition, we provide mechanisms through which abrogation of TGF-beta signaling leads to the enhancement of anti-tumor immunity. Our data indicate that T-cell-specific blockade of TGF-beta signaling has strong therapeutic potential to shift the balance of the immune response in favor of anti-tumor immunity. |
