| First Author | Daley SR | Year | 2007 |
| Journal | J Immunol | Volume | 179 |
| Issue | 6 | Pages | 3648-54 |
| PubMed ID | 17785800 | Mgi Jnum | J:152050 |
| Mgi Id | MGI:4355812 | Doi | 10.4049/jimmunol.179.6.3648 |
| Citation | Daley SR, et al. (2007) A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts. J Immunol 179(6):3648-54 |
| abstractText | TGF-beta is a key immunoregulatory cytokine which supports self-tolerance by signaling to T cells. In this report, we show a crucial role for TGF-beta signaling to T cells in enabling the long-term acceptance of allografts, whether natural or induced therapeutically by coreceptor and costimulation blockade. The requirement for TGF-beta appears most pronounced during the initial exposure to alloantigens. We demonstrate the ability of TGF-beta to direct the development in vitro of regulatory cells that suppress graft rejection in vivo. Such suppression was not affected by anti-TGF-beta treatment of the recipient mice. Despite this, TGF-beta may still have a role in CD4+ cell-mediated suppression of antiallograft responses in vivo, since its neutralization can, in some cases, abrogate suppression. These results show that TGF-beta signaling to T cells is dispensable for mounting destructive responses against skin allografts while appearing to be an essential intermediary in establishing long-term tolerance. |
