| Primary Identifier | MGI:3577652 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Fktn |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
| Is Recombinase | false | Is Wild Type | false |
| description | Chimeric mice are dystrophic with an inability to walk a straightline and drag their feet (J:87120). Muscle weakness is also apparent in a hanging wire grip test and positional instability in the rotor-rod test (J:87120). Several brain and eye abnormalities are also present (J:87120). Myelination of peripheral nerves is defective and the chimeric mouse is a model for Fukuyama-type congenital muscular dystrophy, OMIM ID:253800 (J:122554). |
| molecularNote | A neomycin resistance gene replaced exon 2, removing the sequence encoding amino acids 1-35. |
