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Allele : Park7<tm1Dsp> Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1, David S Park

Primary Identifier  MGI:3576227 Allele Type  Targeted
Attribute String  Null/knockout Gene  Park7
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Exons 3-5 were replaced with a neomycin resistance gene. Exon 1 was modified to contain a premature stop codon, resulting in a transcript containing only the first 8 amino acids. Absence of transcript was confirmed by Northern blot of RNA from mutant MEFs. Absence of protein was shown by Western blot of mutant cortical neurons.
  • mutations:
  • Insertion,
  • Intragenic deletion,
  • Nucleotide substitutions
  • synonyms:
  • DJ-1<->,
  • DJ-1<->,
  • Park7<tm1Mak>,
  • Park7<tm1Mak>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

18 Publication categories

Trail: Allele