| First Author | Garcia SN | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 27 | Pages | 5275-81 |
| PubMed ID | 17961556 | Mgi Jnum | J:127742 |
| Mgi Id | MGI:3764765 | Doi | 10.1016/j.febslet.2007.10.017 |
| Citation | Garcia SN, et al. (2007) Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation. FEBS Lett 581(27):5275-81 |
| abstractText | MORF4-related gene on chromosome 15 (MRG15) is a core component of the NuA4/Tip60 histone acetyltransferase complex that modifies chromatin structure. We here demonstrate that Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit an impaired DNA-damage response post gamma irradiation, when compared to wild-type cells. Defects in DNA-repair and cell growth, and delayed recruitment of repair proteins to sites of damage were observed. Formation of phosphorylated H2AX and 53BP1 foci was delayed in Mrg15 mutant versus wild-type cells following irradiation. These data implicate a novel role for MRG15 in DNA-damage repair in mammalian cells. |
