| First Author | Salcedo M | Year | 1995 |
| Journal | Mol Immunol | Volume | 32 |
| Issue | 11 | Pages | 789-94 |
| PubMed ID | 7675041 | Mgi Jnum | J:28838 |
| Mgi Id | MGI:76377 | Doi | 10.1016/0161-5890(95)00048-j |
| Citation | Salcedo M, et al. (1995) Altered MHC class I presented peptide repertoire is not sufficient to induce NK cell mediated F1-hybrid resistance. Mol Immunol 32(11):789-94 |
| abstractText | Murine NK cells are known to mediate F1-hybrid anti-parental graft rejection responses. This phenomenon has been linked to the MHC, and in particular, to the alpha 1/alpha 2 domains of the MHC class I molecules. Here, we have addressed the role of MHC class I bound peptides in NK cell mediated F1-hybrid anti-parental rejection by studying the resistance of F1-hybrids between B6 and different bm mutant strains to B6-derived RBL-5 lymphoma cell line. Tumor development occurred at a similar frequency in all combinations of (B6 x bm)F1 mice and control B6 mice. These results suggest that absence of a specific MHC class I presented peptide repertoire on grafted cells is not sufficient to induce NK cell mediated F1-hybrid anti-parental rejection responses. |
