Primary Identifier | MGI:3577756 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Igk-Lta/Ltb)4Cys |
Strain of Origin | (C57BL/6J x DBA/2J)F2 | Is Recombinase | false |
Is Wild Type | false |
description | Of the several lines created, lines 4 and 10 both overexpressed the fusion gene on B cells but not on T cells. |
molecularNote | A 450 bp DNA fragment of the Ltb gene coding the transmembrane and membrane-proximal region was fused to a 486 bp fragment of the Lta gene coding for the receptor binding domain. This chimeric construct was placed under the control of an Igk promoter. |