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Publication : Dysfunctional niches as a root of hematopoietic malignancy.

First Author  Shiozawa Y Year  2010
Journal  Cell Stem Cell Volume  6
Issue  5 Pages  399-400
PubMed ID  20452309 Mgi Jnum  J:160606
Mgi Id  MGI:4454717 Doi  10.1016/j.stem.2010.04.004
Citation  Shiozawa Y, et al. (2010) Dysfunctional niches as a root of hematopoietic malignancy. Cell Stem Cell 6(5):399-400
abstractText  Whether the bone marrow microenvironment can contribute to development of blood borne cancers is controversial. In a recent issue of Nature, Raaijmakers et al. (2010) show that deletion of Dicer1 specifically in osteoprogenitors not only impaired their differentiation but also resulted in disrupted blood formation and secondary leukemia.
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