| First Author | Luckey U | Year | 2011 |
| Journal | J Clin Invest | Volume | 121 |
| Issue | 10 | Pages | 3860-71 |
| PubMed ID | 21881208 | Mgi Jnum | J:178231 |
| Mgi Id | MGI:5297740 | Doi | 10.1172/JCI45963 |
| Citation | Luckey U, et al. (2011) T cell killing by tolerogenic dendritic cells protects mice from allergy. J Clin Invest 121(10):3860-71 |
| abstractText | It is well established that allergy development can be prevented by repeated low-dose exposure to contact allergens. Exactly which immune mechanisms are responsible for this so-called low zone tolerance (LZT) is not clear, although CD8 suppressor T cells are known to have a role. Here, we show that TNF released by tolerogenic CD11CD8 DCs located in skin-draining lymph nodes is required and sufficient for development of tolerance to contact allergens in mice. DC-derived TNF protected mice from contact allergy by inducing apoptosis in allergen-specific effector CD8 T cells via TNF receptor 2 but did not contribute to the generation and function of the regulatory T cells associated with LZT. The TNF-mediated killing mechanism was induced in an allergen-specific manner. Activation of tolerogenic DCs by LZT CD8 suppressor T cells and enhanced TNF receptor 2 expression on contact allergen-specific CD8 effector T cells were required for LZT. Our findings may explain how tolerance protects from allergic diseases, which could allow for the development of new strategies for allergy prevention. |
