| First Author | Koizumi A | Year | 1990 |
| Journal | Biochem Biophys Res Commun | Volume | 166 |
| Issue | 1 | Pages | 336-41 |
| PubMed ID | 2154203 | Mgi Jnum | J:21257 |
| Mgi Id | MGI:69280 | Doi | 10.1016/0006-291x(90)91950-w |
| Citation | Koizumi A, et al. (1990) Demonstration of a new mouse mammary tumor virus locus in the genome of the mammary tumor prone strain SHN mouse. Biochem Biophys Res Commun 166(1):336-41 |
| abstractText | Until this report, there have been no detailed analyses of the mouse mammary tumor virus (MMTV) loci in the mammary tumor prone strain SHN. Using a probe, which hybridizes to the env sequence of MMTV, Southern blotting of genomic DNA from the brain after digestion with EcoRI revealed 5 endogenous proviruses: Mtv-1 (4.5kb), Mtv-2 (11 kb), Mtv-8 (6.7kb), Mtv-17 (8.3kb) and a newly-found 6.5-kb fragment. F1-hybrid mice (C3H/He female x SHN male) also possessed the 6.5-kb fragment. Thus, we conclude that the 6.5-kb fragment is unique to SHN mice. Genomic DNA from mammary tumors of SHN mice showed MMTV insertions, suggesting that activation of an oncogene(s) occurred in this strain. |
