| First Author | Misumi I | Year | 2019 |
| Journal | Cell Rep | Volume | 27 |
| Issue | 2 | Pages | 514-524.e5 |
| PubMed ID | 30970254 | Mgi Jnum | J:300299 |
| Mgi Id | MGI:6489040 | Doi | 10.1016/j.celrep.2019.03.030 |
| Citation | Misumi I, et al. (2019) Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection. Cell Rep 27(2):514-524.e5 |
| abstractText | Obesity in humans is associated with poorer health outcomes after infections compared with non-obese individuals. Here, we examined the effects of white adipose tissue and obesity on T cell responses to viral infection in mice. We show that lymphocytic choriomeningitis virus (LCMV) grows to high titer in adipose tissue. Virus-specific T cells enter the adipose tissue to resolve infection but then remain as a memory population distinct from memory T cells in lymphoid tissues. Memory T cells in adipose tissue are abundant in lean mice, and diet-induced obesity further increases memory T cell number in adipose tissue and spleen. Upon re-challenge infection, memory T cells rapidly cause severe pathogenesis, leading to increases in lipase levels, calcification of adipose tissue, pancreatitis, and reduced survival in obese mice but not lean mice. Thus, obesity leads to a unique form of viral pathogenesis involving memory T cell-dependent adipocyte destruction and damage to other tissues. |
