| First Author | Shao TY | Year | 2023 |
| Journal | Science | Volume | 381 |
| Issue | 6664 | Pages | 1324-1330 |
| PubMed ID | 37733857 | Mgi Jnum | J:340954 |
| Mgi Id | MGI:7531595 | Doi | 10.1126/science.adf9325 |
| Citation | Shao TY, et al. (2023) Reproductive outcomes after pregnancy-induced displacement of preexisting microchimeric cells. Science 381(6664):1324-1330 |
| abstractText | Pregnancy confers partner-specific protection against complications in future pregnancy that parallel persistence of fetal microchimeric cells (FMcs) in mothers after parturition. We show that preexisting FMcs become displaced by new FMcs during pregnancy and that FMc tonic stimulation is essential for expansion of protective fetal-specific forkhead box P3 (FOXP3)-positive regulatory T cells (T(reg) cells). Maternal microchimeric cells and accumulation of T(reg) cells with noninherited maternal antigen (NIMA) specificity are similarly overturned in daughters after pregnancy, highlighting a fixed microchimeric cell niche. Whereas NIMA-specific tolerance is functionally erased by pregnancy, partner-specific resiliency against pregnancy complications persists in mothers despite paternity changes in intervening pregnancy. Persistent fetal tolerance reflects FOXP3 expression plasticity, which allows mothers to more durably remember their babies, whereas daughters forget their mothers with new pregnancy-imprinted immunological memories. |
