| First Author | Rodrigues OR | Year | 2006 |
| Journal | Cell Immunol | Volume | 243 |
| Issue | 2 | Pages | 118-26 |
| PubMed ID | 17316586 | Mgi Jnum | J:120728 |
| Mgi Id | MGI:3707903 | Doi | 10.1016/j.cellimm.2007.01.005 |
| Citation | Rodrigues OR, et al. (2006) H-2 complex influences cytokine gene expression in Leishmania infantum-infected macrophages. Cell Immunol 243(2):118-26 |
| abstractText | This work aims to study the influence of H-2 locus in the control of Leishmania infantum infection by evaluating whether cytokine responses by host macrophages of different H-2 haplotype are differentially regulated, either induced or actively impaired during parasite growth and replication. This study shows that macrophages of 'non-cure' phenotype (H-2(d)) are more susceptible to infection with virulent L. infantum promastigotes. Virulent parasites lead to impaired IL-12 and inhibited TNF-alpha expression. The degree of parasite virulence is an important contributing factor to differences detected in cytokine expression. Virulent parasites also induced TGF-beta, a deactivating cytokine that is known to suppress Th-1 type responses, thus allowing the parasite to subvert antimicrobial activity and increase its chances of survival. Depending on specific host haplotype, cells differentially respond to infection since TNF-alpha expression is inhibited and TGF-beta is enhanced by macrophages of 'non-cure' phenotype, thus perhaps determining their degree of susceptibility in this strain of mice. |
