| First Author | Kim YC | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 18 | Pages | 3891-5 |
| PubMed ID | 20708612 | Mgi Jnum | J:164395 |
| Mgi Id | MGI:4833754 | Doi | 10.1016/j.febslet.2010.08.010 |
| Citation | Kim YC, et al. (2010) DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc. FEBS Lett 584(18):3891-5 |
| abstractText | Simian virus 40 (SV40) is a tumor virus and its early gene product large T-antigen (LT) is responsible for the transforming activity of SV40. Parkinson's disease causative gene DJ-1 is also a ras-dependent oncogene, but the mechanism of its oncogene function is still not known. In this study, we found that there were no transformed foci when fibroblasts from DJ-1-knockout mice were transfected with LT. We also found that DJ-1 directly bound to LT and that the expression level of c-Myc in transformed cells was parallel to that of DJ-1. These findings indicate that DJ-1 is essential for SV40 transformation. |
