| First Author | Takahashi Y | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 10 | Pages | 1143-1149 |
| PubMed ID | 25796186 | Mgi Jnum | J:220834 |
| Mgi Id | MGI:5636542 | Doi | 10.1016/j.febslet.2015.03.010 |
| Citation | Takahashi Y, et al. (2015) MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS Lett 589(10):1143-9 |
| abstractText | Aberrant activation of Wnt signaling contributes to ischemia-induced retinal neovascularization in oxygen-induced retinopathy (OIR), although the underlying mechanism is so far unclear. Here, we show that microRNA-184 (miR-184) is significantly down-regulated in the retina of OIR mice, and miR-184 negatively modulates Wnt signaling both in vivo and in vitro. Furthermore, we show that the Wnt receptor, frizzled-7, is a downstream target of miR-184, and delivery of miR-184 mimic inhibits Wnt signaling in the OIR retina. These results suggest that decreased levels of miR-184 are responsible, at least in part, for the aberrant activation of Wnt signaling in ischemia-induced retinal neovascularization. |
