| First Author | Wu PR | Year | 2017 |
| Journal | Cereb Cortex | Volume | 27 |
| Issue | 9 | Pages | 4303-4313 |
| PubMed ID | 27497284 | Mgi Jnum | J:264478 |
| Mgi Id | MGI:6197115 | Doi | 10.1093/cercor/bhw230 |
| Citation | Wu PR, et al. (2017) The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex. Cereb Cortex 27(9):4303-4313 |
| abstractText | Prenatally, the cytokine CXCL12 regulates cortical interneuron migration, whereas its postnatal functions are poorly understood. Here, we report that CXCL12 is expressed postnatally in layer V pyramidal neurons and localizes on their cell bodies in the medial prefrontal cortex (mPFC), while its receptors CXCR4/CXCR7 localize to the axon terminals of parvalbumin (PV) interneurons. Conditionally eliminating CXCL12 in neonatal layer V pyramidal neurons led to decreased axon targeting and reduced inhibitory perisomatic synapses from PV+ basket interneurons onto layer V pyramidal neurons. Consequently, the mPFC of Cxcl12 conditional mutants displayed attenuated inhibitory postsynaptic currents onto layer V pyramidal neurons. Thus, postnatal CXCL12 signaling promotes a specific interneuron circuit that inhibits mPFC activity. |
