| First Author | Pirottin D | Year | 2005 |
| Journal | Proc Natl Acad Sci U S A | Volume | 102 |
| Issue | 18 | Pages | 6413-8 |
| PubMed ID | 15851664 | Mgi Jnum | J:98460 |
| Mgi Id | MGI:3578498 | Doi | 10.1073/pnas.0502426102 |
| Citation | Pirottin D, et al. (2005) Transgenic engineering of male-specific muscular hypertrophy. Proc Natl Acad Sci U S A 102(18):6413-8 |
| abstractText | Using a two-step procedure involving insertional gene targeting and recombinase-mediated cassette exchange in ES cells, we have produced two lines of transgenic mice expressing a dominant-negative latency-associated myostatin propeptide under control of the myosin light chain 1F promoter and 1/3 enhancer from the TSPY locus on the Y chromosome. Males of the corresponding lines are characterized by a 5-20% increase in skeletal muscle mass. This experiment demonstrates the feasibility of a more efficient cattle production system combining superior beef production abilities for bulls and dairy abilities for cows. |
