| Primary Identifier | MGI:3583693 | Gene | Aecp |
| Inheritance Mode | Recessive | Strain of Origin | C57BL/10 |
| Is Recombinase | false | Is Wild Type | false |
| description | Dexamethasone given intraperitoneally on the twelfth day of pregnancy can induce cleft palate in mouse embryos. Two Chr 17 genes control sensitivity to dexamethasone, Dxcp1 and Dxcp2. It has been found that supplementation of the diet of the pregnant dams with excess vitamin A can increase susceptibility to the effect of dexamethasone. The vitamin A effect is mediated by a recessive locus, Aecp, which lies proximal to the Dxcp2 gene (J:4301). |
| molecularNote | The b allele at H2-S and H2-D1 is associated with sensitivity to vitamin A induced cleft palate. The d and k alleles at H2-S and H2-D1 are associated with resistance to vitamin A induced cleft palate. |
