| First Author | Tyan ML | Year | 1987 |
| Journal | J Immunogenet | Volume | 14 |
| Issue | 4-5 | Pages | 239-45 |
| PubMed ID | 3454798 | Mgi Jnum | J:103482 |
| Mgi Id | MGI:3609553 | Doi | 10.1111/j.1744-313x.1987.tb00386.x |
| Citation | Tyan ML (1987) Vitamin A-enhanced cleft palate susceptibility associated with H-2. J Immunogenet 14(4-5):239-45 |
| abstractText | Pregnant mice from the congenic strains C57BL/10Sn, B10.BR, B10.A/SgSn, B10.A(5R)/SgSn, B10.A(2R)SgSn and B10.A(18R)Sg were fed Purina Laboratory Chow or the same diet plus approximately 400 IU vitamin A daily and given 80 mg/kg dexamethasone intra-peritoneally or a sham injection on the 12th day of pregnancy. It was found that only strains with b alleles between H-2S and H-2D had significantly higher frequencies of isolated cleft palate among their progeny when fed the supplemental vitamin A. The locus appears to be on the centromeric side of a dexamethasone-induced cleft palate gene which has been mapped to the same general area. |
