| Primary Identifier | MGI:3583258 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Ins2-OVA)59Wehi |
| Strain of Origin | B6.C-H2<bm1>/ByJWehi | Is Recombinase | false |
| Is Wild Type | false |
| description | The pancreatic islets of transgenic mice exhibit weak ovalbumin- (OV-) specific immunohistologic staining. Western blot analysis measures the islet OV content as 1.0 +/- 0.4 ng/'ug of protein. These mice develop diabetes following adoptive transfer of activated, but not naive, CD8+ T lymphocytes from mice bearing Tg(TcraTcrb)1100Mjb (OT-1). |
| molecularNote | Mice bearing this transgene express a secreted form of ovalbumin from the full-length chicken ovalbumin cDNA under control of the rat insulin 2 promoter. |
