| Primary Identifier | MGI:3583662 | Allele Type | Targeted |
| Gene | Psen1 | Transmission | Germline |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | An I213T (p.Ile213Thr) mutation was introduced into exon 7. A neomycin resistance (Neo) gene flanked by two loxP sites was inserted into intron 6 for selection and was subsequently removed via cre-mediated recombination. Northern blot and RT-PCR demonstrated that the levels of transcript in mutants were comparable to that in wild-type. Elevated levels of the amyloid beta peptide 42 were dected in homozygous mice. |
