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Publication : Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development.

First Author  Asher DR Year  2005
Journal  Genesis Volume  42
Issue  2 Pages  77-85
PubMed ID  15864812 Mgi Jnum  J:99585
Mgi Id  MGI:3583046 Doi  10.1002/gene.20127
Citation  Asher DR, et al. (2005) Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development. Genesis 42(2):77-85
abstractText  The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that is known to be a site of viral attachment and entry, but its physiologic functions are undefined. CAR expression is maximal in neonates and wanes rapidly after birth in organs such as heart, muscle, and brain, suggesting that CAR plays a role in the development of these tissues. Here, we show that CAR deficiency resulted in an embryonic lethal condition associated with cardiac defects. Specifically, commencing approximately 10.5 days postconception (dpc), CAR-/- cardiomyocytes exhibited regional apoptosis evidenced by both histopathologic features of cell death and positive staining for the apoptotic marker cleaved caspase 3. CAR-/- fetuses invariably suffered from degeneration of the myocardial wall and thoracic hemorrhaging, leading to death by 11.5 dpc. These findings are consistent with the view that CAR provides positive survival signals to cardiomyocytes that are essential for normal heart development.
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