| First Author | Chau KY | Year | 2005 |
| Journal | Int Immunol | Volume | 17 |
| Issue | 3 | Pages | 297-306 |
| PubMed ID | 15710911 | Mgi Jnum | J:96685 |
| Mgi Id | MGI:3531250 | Doi | 10.1093/intimm/dxh209 |
| Citation | Chau KY, et al. (2005) IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1. Int Immunol 17(3):297-306 |
| abstractText | We report for the first time that IFNG gene expression requires high mobility group (HMG)A1, the architectural transcription factor mediating enhanceosome formation. This finding is supported by our direct studies of T cells isolated from the HMGA1-transgenic mice displaying an up-regulation of IFN-gamma production and of HMGA1-deficient mice exhibited a decreased IFN-gamma induction. In parallel transfection studies in EL4 cells, we observed elevated IFNG gene promoter activity in cells stably over-expressing HMGA1 and a reduction of such activity in cells expressing dominant-negative HMGA1. In vitro binding assays further demonstrated a specific interaction of HMGA1 to defined regions of the IFNG gene proximal promoter. |
