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Publication : Grg1 acts as a lung-specific oncogene in a transgenic mouse model.

First Author  Allen T Year  2006
Journal  Cancer Res Volume  66
Issue  3 Pages  1294-301
PubMed ID  16452182 Mgi Jnum  J:106684
Mgi Id  MGI:3619204 Doi  10.1158/0008-5472.CAN-05-1634
Citation  Allen T, et al. (2006) Grg1 acts as a lung-specific oncogene in a transgenic mouse model. Cancer Res 66(3):1294-301
abstractText  Groucho proteins are transcriptional corepressors that are recruited to gene regulatory regions by numerous transcription factors. Long isoforms, such as Grg1, have all the domains of the prototype Drosophila Groucho. Short Groucho proteins, such as Grg5, have only the amino-terminal Q and G/P domains. We generated Grg1 and Grg5 transgenic mice and found that Grg1 overexpression induces lung adenocarcinoma, whereas Grg5 overexpression does not. Coexpression of Grg5 with Grg1 reduces tumor burden. Grg1 and Grg5 both diminish p53 protein levels; however, only Grg1 overexpression induces elevated levels of ErbB1 and ErbB2 receptor tyrosine kinases. The molecular and biological changes that accompany tumor progression in Grg1 transgenic mice closely reiterate events seen in human lung cancer. We also found that within a human lung tumor tissue array, a significant number of carcinomas overexpress Grg1/TLE1. Our data suggest that Grg1 overexpression contributes to malignancy in human lung cancers.
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